Dysregulation of the translational control pathways caused by Aβ oligomers will affect the protein products of FMRP targets, including Aβ precursor protein (APP), ARC, STEP, PTEN, GSK3β and other molecules which are closely linked to AD or other neurodegenerative disorders (Figure 1A), further associating FMRP with neurodegeneration. The gene discussed is APP; the disease is Alzheimer disease.