NFKB1 and colorectal cancer: The probable mechanism is allicin works on the kinase upstream, and then P38 and JNK regulate downstream target NF-κB. A study focusing on diallyl disulfide (DADS) [35], a component of garlic, indicated that addition of 25, 50, 100, and 500 μmol/L DADS to human colorectal cancer cells (HCT-15 cells) elevates ERK phosphorylation by 39, 52, 73, and 61%, respectively.