It also modulates NF-κB transcriptional and DNA binding activity, suppresses NF-κB antiapoptotic target genes (Bcl-2, cIAP1/2) and inflammatory target genes (iNOS and COX-2), and consequently, as observed in human SW620 and HCT116 colon cancer cells, induces apoptosis [11]. The gene discussed is NFKB1; the disease is colonic neoplasm.