Previous studies have highlighted Wnt7a as a tumor suppressor in a number of epithelial-cell-derived cancers.18, 19, 23 In the current study, we utilized the Wnt7a germline null mouse as a physiologically relevant model to evaluate the role of Wnt7a in lung tumorigenesis25 (The Jackson laboratory, Bar Harbor, ME, USA; stock number 004715). This evidence concerns the gene WNT7A and neoplasm.