WNT7A and neoplasm: Iloprost, a synthetic analog of prostacyclin (PGI2), was shown to reduce the tumor number in mice via receptor binding and initiation of downstream signaling cascades similar to that of Wnt7a.44 Moreover, Iloprost was shown to improve endobronchial dysplasia in former smokers in a recent clinical trial.45 As Iloprost was shown to function as a Wnt7a mimic,44 we tested whether Iloprost treatment of NSCLC cells could trigger cellular senescence similar to Wnt7a (Figures 5f and g).