Interestingly, unlike other Wnts, Wnt7a has been shown to have an important tumor-protective role, particularly in the lung.18, 19, 23 Strikingly, Wnt7a is lost in many non-small cell lung cancer (NSCLC) cell lines and tissues, primarily via promoter methylation24 and restoration of Wnt7a expression in NSCLC cell lines prompts cellular differentiation and reversal of the transformed phenotype.18, 19 Given the importance of Wnt7a in tumor suppression, we sought to define the mechanism/s through which Wnt7a exerts its tumor-protective role. Here, WNT7A is linked to non-small cell lung carcinoma.