The PPP is an important metabolic pathway that is related with cancer, specifically in augmenting tumor proliferation by supplying tumor cells with NADPH22, 23; modulation of metabolic enzymes involved in both oxidative and nonoxidative PPP24; and modulation of glycolytic flux through regulation of the glycolysis rate-limiting enzyme Glycolysis Phosphofructokinase-1 (PFK-1)24. Here, PFKM is linked to cancer.