Additionally, genes involved in fatty acid metabolism (Enoyl-CoA Delta Isomerase 2 [ECI2] and Prostaglandin E Synthase 2 [PTGES2]) were identified as TAL1 targets, further highlighting the role of metabolism in cancer, long observed by Warburg25 and confirmed in recent studies22, 24, 26. This evidence concerns the gene PTGES2 and cancer.