To address this, we have studied the effects of DSS/AOM‐induced colitis‐associated carcinogenesis in mice carrying germline deletions of the Nfkb1, Nfkb2 or c‐Rel genes and have also investigated the impact of these deletions on DSS‐induced colitis and colonic responses to DNA damage. This evidence concerns the gene NFKB2 and colitis.