MAPK8 and type 1 diabetes mellitus: Moreover, in terms of a pathway ‘response to oxidative stress’, we were able to identify the link between RGD1560648 (DJ1) and Mapk8/MK08_Rat (JNK1) (function-based relationship between DJ1 and JNK1, see Fig.8B), which allowed us to predict the association of DJ1 with JNK1 in T1DM, and it was further validated by co-immunoprecipitation (Co-IP; Fig.9).