HGF and neoplasm: In addition, HGF neutralizing monoclonal antibodies [8], c-met antisense oligonucleotides [9], dominant-negative forms of the c-Met protein [10], ribozyme-mediated reduction of c-Met expression [11, 12], and dual-function decoy c-Met receptor [13] are also being investigated as possible strategies to block c-Met activation and suppress tumor growth, invasion, and metastasis.