EPAS1 and colorectal cancer: The percentage of colorectal cancer samples with positive HIF-2α staining is much higher in late stages (stages III & IV) than in early stages (stages I & II) (45% in stage I, 10 of 22 cases; 63% in stage II, 146 of 232 cases; 91% in stage III, 20 of 22 cases; and 88% in stage IV, 7 of 8 cases).