By analyzing data from The Cancer Genome Atlas (TCGA) (http://cancergenome.nih.gov/), we found that mRNA expression of the COX4I1 gene, which encodes COX4-1, is significantly correlated with the expression of BMI1 mRNA in patients with high-grade GBM (Pearson correlation, p < 0.0001) (Figure 1C). The gene discussed is BMI1; the disease is cancer.