DEB can be either dominant or recessive (then called recessive dystrophic epidermolysis bullosa or RDEB), with mutations in gene coding for collagen type VII (COL7A1) that localizes to the anchoring fibrils, structures that ensure the adhesion of the basal lamina with the extracellular matrix (Bruckner-Tuderman et al, 1999). This evidence concerns the gene COL7A1 and recessive dystrophic epidermolysis bullosa.