The identification of “BMP signalling pathway” as a regulator of Aβ42 is also consistent with observations that blocking TGF-β–Smad2/3 immune signalling attenuates brain parenchymal and cerebrovascular amyloid deposits in Tg2576 mice, an animal model of AD that overproduces Aβ42[46]. This evidence concerns the gene TGFB1 and Alzheimer disease.