In addition, we demonstrate how pathway-based analysis can be used to: (1) identify the interplay across different regulatory pathways/processes; (2) understand how production of APP peptides can be regulated by common or distinct mechanisms; (3) propose mechanistic hypotheses as to how a diabetes-related pathway can affect APP processing and (4) provide a framework from which novel amyloid therapeutic strategies could be derived. This evidence concerns the gene APP and diabetes mellitus.