Therefore, we investigated the association of tSNPs in RAS gene (ACE gene rs8066114, AGT gene rs7539020, rs3789678, rs2478544, rs11568023, rs2478523, rs4762, rs699 and CYP11B2 rs3802230, rs3097) and atrial fibrillation in a Chinese Han sample. The gene discussed is ACE; the disease is atrial fibrillation.