HIF1A and chronic obstructive pulmonary disease: A recent study indicated that LMWH alleviated inflammation and fibrosis in rats’ lung tissue with chronic obstructive pulmonary disease (COPD), through inhibiting the expression of HIF-1α and its downstream target genes VEGF (Vascular Endothelial Growth Factor) [9], which is a well-known growth factor that promotes neoangiogenesis.