Activated EGF/EGFR pathway may promote cell proliferation, differentiation, angiogenesis, and anti-apoptosis in HNSCC tumorigenesis and progression through the phosphoinositide-3-kinase (PI3K)/Akt, ras/raf/extracellular regulated protein (Erk), and signal transducer and activator of transcription pathways [9, 10]. This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.