NSD2 and non-Hodgkin lymphoma: These genes included BRPF3, RCOR1, WHSC1L1, WHSC1, CHD6, KDM5C, SMARCA4, MLL2/KMT2D, and EP300. Although the number of targeted chromatin modifiers was not sufficient to statistically enrich the chromatin modification GO Term (GO:0016568), two of these candidate targets (MLL2/KMT2D and EP300) are frequently mutated in NHL [23] (Figure 4a and b).