CD28 and diffuse large B-cell lymphoma: Our integrative analysis revealed that miR-148a candidate targets included genes associated with immune response (GO:0006955); for example, AMICA1, CCR5, CD28, CD3G, CD8A, CD96, CLEC10A, CSF1, CTSW, CXCL12, CXCL16, GZMM, ITK, LCP2, MX2, NUB1, OASL, PRKCQ, SAMHD1, SELL, SIGIRR, TMEM173, and XCL1. Of note, CXCL12 is a chemokine receptor which plays a role in germinal center homing [26] and CCR5 expression is associated with the transformation of mucosa-associated lymphoid tissue (MALT) lymphoma to DLBCL [27].