Finally, we use the term VRFs to refer to traditional risk factors for atherosclerosis (for example, hypertension, diabetes mellitus, and hyperlipidemia) and not for amyloid angiopathy (for example, apolipoprotein E (ApoE) ε4 is mentioned distinctly and not included under the label VRF in this review). The gene discussed is APOE; the disease is Hypertension.