CXCL10 and colitis: Pioglitazone significantly reduced CXCL10 levels in two models of colitis (dextran sodium sulfate and 2,4,6-dinitrobenzene sulfonic acid-mediated colitis) and dose-dependently reduced CXCL10 levels from activated HT-29 colon epithelial cells and THP-1-derived macrophages [65].