TNF and geroderma osteodysplastica: More recently, our group showed the effects of the IFN-γ + TNF-α-stimulation and of increasing concentrations of the PPAR-γ agonists (pioglitazone or RGZ) on the Th1-chemokine CXCL10 and the Th2-chemokine (C-C motif) ligand (CCL)2 secretion in primary cultures of extraocular muscle (EOM) cells from GO patients [100].