Pioglitazone inhibited dose-dependently the IFN-γ + TNF-α-induced CXCL10 secretion in thyrocytes, orbital fibroblasts, and preadipocytes from GO patients, while RGZ and pioglitazone reduced the IFN-γ + TNF-α activation of NF-kB in GD thyrocytes [98]. This evidence concerns the gene CXCL10 and geroderma osteodysplastica.