We have previously shown that dietary administration of a 1% CLA blend of the two most abundant isomers (80:20, cis-9,trans-11-CLA:trans-10,cis-12-CLA) induces regression of pre-established atherosclerosis in the apo-E−/− mouse model, despite a continuing high cholesterol challenge [25], via modulation of monocyte/macrophage function [29,30]. Here, APOE is linked to atherosclerosis.