To date, the effect of CLA on the modulation of macrophage/foam cell phenotype and function have primarily been conducted in cell lines, in particular the murine RAW-264.7 [35,36] and the human THP-1 cells [29], as well as in murine [27] and rabbit models of atherosclerosis [21,28,42]. The gene discussed is SELPLG; the disease is atherosclerosis.