The relevance of ATXN2 for the secretion of lipid trafficking factors was also shown in a recent study of the blood plasma proteome of SCA2 patients, where the significant dysregulation of 9 factors was documented, including a 4-fold decrease in apolipoprotein C3, a 3-fold decrease in apolipoprotein A1, a 2-fold decrease in aplipoprotein C2 and a > 4-fold increase in apolipoprotein E [69]. The gene discussed is APOA1; the disease is spinocerebellar ataxia type 2.