The differences between these two proteins still remain elusive.8, 9 The function of β-TrCPs in tumorigenesis is either oncogenic or tumor-suppressive in a tissue-specific or cellular context-dependent manner homology.8, 9 Although it has been widely studied that β-TrCP recognizes diverse proteins and regulates their stability, the regulation of β-TrCP itself is not yet understood. The gene discussed is BTRC; the disease is neoplasm.