FBXW7 and melanoma: It has been reported that β-TrCP stabilizes c-Myc through antagonizing FBW7-mediated turnover.20 It has been also demonstrated that activation of Ras/PI3K/ERK pathway induces c-Myc stabilization in melanoma cells,21 and inhibition of PI3K/AKT pathway by LY294002 in melanoma cells,21 or by PI-103 in Burkitt's lymphoma cells,22 and reduces c-Myc expression.