Soluble VEGFR-1 (sVEGFR-1), but not sVEGFR-2, -3, and basic fibroblast growth factor (bFGF, alternatively known as FGF-2), have been reported to be increased in pre-operatively collected serum samples from newly diagnosed glioblastoma patients [39, 131]. This evidence concerns the gene FGF2 and glioblastoma.