ALK and melanoma: Examples are the Cobas 4800 BRAF V600 Mutation Test (Roche Molecular Systems Inc.)which detects the BRAF V600E mutation in formalin-fixed, paraffin-embedded (FFPE) human melanoma tissue and the Vysis ALK Break Apart FISH Probe Kit (Abbott Molecular Inc.), which detects rearrangements involving the ALK gene via fluorescence in situ hybridization (FISH) in FFPE tissue.