CD177 and acute respiratory distress syndrome: Under pathological conditions, dysfunctional endothelial cells also show altered intracellular trafficking and signaling of cell surface receptors, such as TGFβ-RI, which is implicated in the pathogenesis of ALI/ARDS (Kranenburg et al., 2002; Morrell et al., 2001; Sehgal and Mukhopadhyay, 2007; Voelkel and Cool, 2003).