Our in situ analysis reinforced the notion that purified LukGH and PVL triggers a profound inflammatory response, as evidenced by increased expression of mRNAs encoding IL-8, IL-6, IL-1β, TNFα, IL-17A and IL-17F in a rabbit abscess model—a finding consistent with previous in vivo and in vitro studies [14,27]. Here, TNF is linked to abscess.