For example, cFLIP is reported to have a central role in conferring TRAIL resistance to melanoma52, 53 and glioblastoma,54, 55 and several TRAIL-resistant melanoma and glioblastoma cell lines were sensitized by withanolide E to TRAIL-induced apoptosis (see Supplementary Information). This evidence concerns the gene TNFSF10 and glioblastoma.