42 Increased phosphorylation of PKR/eIF2α was also observed in muscles from diabetic mice.43 Since Drp1 expression levels increases in cachexia and type 2 diabetes models,12, 13 it is possible that some of the events that we observed in Drp/MC muscle are also responsible for the depression in protein synthesis observed in these pathologies. The gene discussed is EIF2AK2; the disease is Cachexia.