PHB1 and neoplasm: Prohibitin 1 (PHB) has been shown to significantly impact cellular senescence and development, as well as suppression of tumor cell proliferation.7, 8, 9, 10, 11 Unfortunately, loss of prohibitin subunits is associated with embryonic lethality in multicellular organisms such as C. elegans12 and mice,13, 14 hampering functional studies on mammalian prohibitins at the organismal level.