A recent study has shown that overexpressed Akt phosphorylates PHB on Thr258 in vitro and that it is also capable of doing so in vitro on overexpressed PHB in HEK-293T cancer cells.25 Our group is particularly interested in understanding the functional significance of Akt-induced phosphorylation on PHB and its downstream effects on BC cells. The gene discussed is AKT1; the disease is breast cancer.