ADAMTS1 encodes a protease highly upregulated in MDA-MB-231 subclones endowed with high metastatic potential.27 It has also been shown essential to mammary tumorigenesis in PyMT model of mammary tumor development14 and to metastasis in xenografted MDA-MB-231 cells.13 Interestingly, the decreased tumorigenesis observed in PyMT/ADAMTS1−/− mice was characterized by increased apoptosis.14 It is thus tempting to speculate that decreased ADAMTS1 expression seen in NFAT1-silenced tumors contributes to their apoptotic phenotype. The gene discussed is NFATC2; the disease is breast cancer.