YAP1 and neoplasm: Knockdown of upd3 alone in neoplastic tumors does not prevent overgrowth (Figure 2—figure supplement 1); upd1 and upd2 are also regulated by JNK, Yki, and PcG (Pastor-Pareja et al., 2008; Classen et al., 2009; Jiang et al., 2009; Staley and Irvine, 2010; Wu et al., 2010) and may act through analogous enhancers to cooperatively drive tumor formation.