While the phenotypes of mab21l2 morphants and mutants show overlap, some ocular features, including severe lens degeneration, coloboma, and early retinal invagination defects, appear to be more pronounced or observed primarily in genetic mutants; this may be due to incomplete disruption of mab21l2 function via morpholino, the transient nature of morpholino-induced effects, and/or genetic background differences. Here, MAB21L2 is linked to coloboma.