Tumor expression of LC3 was linked with impaired glucose metabolism (P = 0.0205), larger tumor size (P = 0.0453), tumor dedifferentiation (P = 0.0040), vascular invasion (P = 0.0044), lymphatic invasion (P = 0.0385), while stromal expression of LC3 associated with tumor dedifferentiation (P<0.0001), positive marginal status (P = 0.0010), negative vascular invasion (P = 0.0015) (Table 4). The gene discussed is MAP1LC3A; the disease is neoplasm.