RASAL1 and renal fibrosis: Our findings that Rasal1 promoter CpG island methylation contributed to progression of renal fibrosis, Hydralazine ameliorated aberrant promoter methylation, and blunted renal fibrosis and intrarenal Rasal1 promoter methylation levels correlate with Hydralazine therapy in mice offered the attractive combination of a clinically approved drug (Hydralazine and its derivate Dihydralazine) and a potential biomarker in human patients (RASAL1 promoter methylation).