Correlation between Urinary NAG level and Albumin/creatinine ratio, serum creatinine and HbA1c showed significant + ve Correlation between Urinary NAG level and all previous parameters , this coincides with Sato et al. [31] stated that NAG total activity and A2 isoenzyme were highly correlated with the level of proteinuria with A2/A1 ratio higher in glomerular diseases (e.g. glomerulonephritis and diabetic nephropathy) than tubulointerstitial pathologies (e.g. chronic pyelonephritis and polycystic kidney). The gene discussed is ALB; the disease is polycystic kidney disease.