Moreover Jamal et al. [21] in their retrospective study to assess the factors affecting the progression of diabetic nephropathy and its complications, they showed an average of 3.3 mL/year drop in GFR and even greater among patients who reached ESRD (5.9 mL/year) and the presence of persistent proteinuria was a strong risk factor for subsequent loss of GFR so they re-emphasizing earlier reports that established the importance of sustained increases in urine albumin excretion in the pathogenesis and diagnosis of diabetic kidney disease. The gene discussed is ALB; the disease is diabetic kidney disease.