KIT and neurofibromatosis type 1: GIST can occur sporadically or concurrently with genetic syndromes, including familial GIST with germline KIT mutation, neurofibromatosis type 1, Carney triad and Carney–Stratakis syndrome (Benesch et al. 2009; Guhyun K et al. 2013; Park et al. 2006; Vaughan et al. 2011).