HTR1A and Lewy body dementia: Based upon these recent findings, it seems plausible that in response to the severely damaged and degenerated raphe nuclei, a selective postsynaptic 5-HT1A receptor upregulation and relative preservation of the 5-HTT reuptake sites might be triggered, specifically in depressed DLB patients, to compensate for the decreased serotonergic neurotransmission from these nuclei towards their neocortical and limbic projection areas [3,25].