VEGFA and hereditary hemorrhagic telangiectasia: Several clinical reports noted that HHT patients treated systemically with 5-10 mg/kg of bevacizumab, a humanized anti-VEGF antibody, showed a significant improvement in the frequency of epistaxis, number of required blood transfusions and that some patients no longer needed a liver transplantation (Mitchell et al., 2008; Bose et al., 2009; Oosting et al., 2009; Retornaz et al., 2009).