Four missense mutations in the KCNT1 gene (Table 1), coding for a Na+-gated K+ channel (KCNT1 or KCa4.1, also known as Slo2.2 or Slack), were associated to severe ADNFLE with psychiatric symptoms, and a penetrance of 100% (Heron et al., 2012). The gene discussed is KCNT1; the disease is autosomal dominant nocturnal frontal lobe epilepsy.