We addressed this question by revealing the short- and long-term (up to 21 days post infection) effect of human let-7c, miR-34a and miR-124a overexpression or inhibition on the viral replication, spread and presence in the JLTRG-R5 and HeLa-CCR5 cells and the virion release to the supernatant by these cells. This evidence concerns the gene CCR5 and infection.