Fluctuations of cyclin A1 and cyclin B1 normally reach a peak in the G2-M transition of the cell cycle22, and in this study, the expression levels of the cyclins were downregulated significantly in the glioma cells overexpressing SNORD76 (Fig. 3B), corresponding to a cyclin-expression pattern of S phase arrested cells. Here, CCNB1 is linked to central nervous system cancer.