Freshly isolated CD45RA+ rTregs have an epigenetically stable FOXP3 locus with extensive TSDR demethylation.46 TSDR demethylation correlates with stable FOXP3 expression in vitro50 and Treg-mediated protection from autoimmunity in vivo57 in humans. The gene discussed is FOXP3; the disease is Autoimmunity.