To examine potential downstream signaling from angptls and notch, we looked at the previously identified target of notch, myc. The relationship between NOTCH and MYC has been best studied in T-ALL cells whereby MYC transduces growth and survival signals to many NOTCH-dependent T-ALL cell lines and forced ectopic expression of MYC can restore the leukemogenic signals for these cells in instances when NOTCH is inhibited (Palomero et al., 2006; Weng et al., 2006; Chan et al., 2007). Here, MYC is linked to acute lymphoblastic leukemia.