To further assess the molecular signaling downstream of zangptls and notch, we examined a known target of notch, myc, and its relationship with respect to zangptls. The MYC proto-oncogene has been previously shown to be a direct NOTCH target in T-cell acute lymphoblastic leukemia (T-ALL) (Palomero et al., 2006; Weng et al., 2006). Here, MYC is linked to acute lymphoblastic leukemia.