Although the newly identified miR-188-5p/LAPTM4B/PI3K/AKT signaling pathway offers new insights into the pathogenesis of PCa and a potential therapeutic target for PCa treatment, the molecular mechanism silencing the expression of the miR-188-5p in PCa is still unknown, analysis of the detailed molecular mechanism will be necessary in future studies. This evidence concerns the gene AKT1 and posterior cortical atrophy.