Although it has been reported that p62 mediates apoptosis and cisplatin resistance by preventing apoptosis in various cell types that harbor a range of different molecular networks [39, 44], p62 was shown in this study to be functionally irrelevant to cell viability and to have no effect on the response to cisplatin treatment of HNSCC cells. The gene discussed is SQSTM1; the disease is head and neck squamous cell carcinoma.