Based on immunohistochemical (IHC) analysis of the human ESCC tissue microarrays, the average fold increases for these three targets in the malignant tissues were as follows: ~3.2 (β-catenin; p<0.001), ~3.1 (FoxM1; p<0.001), and 6.3 (SLC2A1; p<0.001), compared to normal tissue (set at 1.0) (Fig. 5B, 5D, 5F). Here, FOXM1 is linked to esophageal squamous cell carcinoma.