E2F3 and neoplasm: In an effort to confirm a clinical relevance of miR-199a-5p dysregulation and E2F3 upregulation, we measured miR-199a-5p expression in human samples (n = 59, in each group); miR-199a-5p levels were significantly lower in HCC specimens than in adjacent non-tumor liver tissues, indicative of miR-199a-5p dysregulation in tumor samples (Figure 4C).