Given that SETD2 plays a tumor suppressor role and miR-106b-5p has been found responsible for post-transcriptional inhibition of SETD2 in our study, we further explored whether attenuation of miR-106b-5p could suppressed ccRCC cell biologic activity through up-regulation of SETD2. Here, SETD2 is linked to nonpapillary renal cell carcinoma.