PMAIP1 and mantle cell lymphoma: There were no changes seen in the methylation of CpGs covered by primers 3, 4, and 5 corresponding to nucleotides −426 to +975 and located within CpG island in the promoter region of the PMAIP1 gene in MCL cell samples 24 hours after BZM treatment and 72 hours after DAC treatment (data not shown).