Interestingly with patient O340 a clear increase in the proportion of mature T-cells (CD3) (x34), T-helper cells (CD4) (x9) and cytotoxic T-cells (CD8) (x26) is seen, while CD11c-positive cells, B-cells (CD19) and CD25-positive cells (including eg. regulatory T-cells) virtually disappeared from the tumor. The gene discussed is CD8A; the disease is neoplasm.