Soleus muscle denervation induces the tissue-specific insulin resistance in which the mechanism is involved in the decreased expression and phosphorylation in the pivotal downstream signaling molecules of insulin receptor including insulin receptor substrate-1 (IRS-1), phosphatidylinositol 3-kinase (PI3K), and protein kinase B (Akt) [1, 7]. The gene discussed is AKT1; the disease is Insulin resistance.