MDM2 and lipoma: Moreover, identifying MDM2 amplification, as well as overexpression of the corresponding MDM2 protein by immunohistochemistry, has proved an adjunctive tool in the diagnosis of lipomatous neoplasms, especially in the diagnosis of a well-differentiated liposarcoma, because MDM2 amplification is absent in “ordinary” lipomas (Figures 2 and 3) (78–81).