Chromosomal imbalances additionally to the 12q13-q15 amplicon, including amplifications in 1p32 (including JUN), 1q21-q24, and/or 6q23 (including the ASK1 or MAP3K5 gene), have been reported to be more frequent in dedifferentiated liposarcoma than in well-differentiated liposarcoma (69). This evidence concerns the gene MAP3K5 and liposarcoma.