PNPLA3 and cryohydrocytosis: Several studies reported that a PNPLA3 polymorphism was associated with fibrosis in patients with CHC (Valenti et al. 2011; Trepo et al. 2011; Valenti et al. 2012; Dunn et al. 2014), while other studies did not find an association between a PNPLA3 polymorphism and fibrosis (Zampino et al. 2013; Rembeck et al. 2012; Miyashita et al. 2012; Nakamura et al. 2013).