This analysis showed that older age (OR = 1.19; 95% CI: 1.08–1.32; p = 0.0007), and PNPLA3 genotype GG (OR = 3.95; 95% CI: 1.00–15.61; p = 0.0497) were factors independently associated with the development of HCC. Here, PNPLA3 is linked to hepatocellular carcinoma.