A meta-analysis performed by Trepo et al. showed that a PNPLA3 polymorphism was strongly associated with HCC, although the association was stronger in patients with alcoholic liver disease (OR = 2.20; 95% CI: 1.802.67; P = 4.71 × 10−15) than that in patients with CHC (OR = 1.55; 95% CI: 1.03–2.34; P = 3.52 × 10−2) (Trepo et al. 2014). This evidence concerns the gene PNPLA3 and cryohydrocytosis.