However, several reports have not found an association of PNPLA3 polymorphisms with fibrosis and carcinogenesis in CHC (Trepo et al. 2011; Nischalke et al. 2011; Rembeck et al. 2012; Miyashita et al. 2012; Takeuchi et al. 2013; Nakamura et al. 2013; Guyot et al. 2013). This evidence concerns the gene PNPLA3 and cryohydrocytosis.