This analysis showed that older age (OR = 1.05; 95% CI: 1.02–1.09; p = 0.0034), and PNPLA3 genotype GG (OR = 3.35; 95% CI: 1.13–9.91; p = 0.0291) were factors independently associated with progression to cirrhosis. This evidence concerns the gene PNPLA3 and Cirrhosis.