PNPLA3 and hepatocellular carcinoma: Because the associations of PNPLA3 are not strong for fibrosis (OR = 3.13; 95% CI: 1.50–6.51; P = 0.002) (Trepo et al. 2011) and development of HCC (Trepo et al. 2014), a large number of more homogenous patients should be studied to establish an association by statistical analysis.