PNPLA3 polymorphisms have also been reported to be associated with hepatic steatosis, fibrosis, treatment response, and carcinogenesis in CHC (Valenti et al. 2011; Trepo et al. 2011; Cai et al. 2011; Valenti et al. 2012; Clark et al. 2012; Dunn et al. 2014; Ezzikouri et al. 2014; Moritou et al. 2013; Zampino et al. 2013; Trepo et al. 2014; Sato et al. 2013). This evidence concerns the gene PNPLA3 and fatty liver disease.