PNPLA3 and Cirrhosis: This analysis showed that older age (OR = 1.06; 95% CI: 1.03–1.09; p < 0.0001), higher BMI values (OR = 1.12; 95% CI: 1.03–1.22; p = 0.0082), and PNPLA3 genotype GG (OR = 2.07; 95% CI: 0.97–4.42; p = 0.0599) were factors independently associated with progression to cirrhosis, although the association with PNPLA3 genotype GG was only a tendency.