A significant association was reported between a PNPLA3 polymorphism and HCC in patients with CHC (Valenti et al. 2011; Ezzikouri et al. 2014), while other studies did not find a significant association(Nischalke et al. 2011; Guyot et al. 2013). This evidence concerns the gene PNPLA3 and hepatocellular carcinoma.